Antibacterial Activities of Some Transition Metal Schiff Base Complexes

Abstract

A new series of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylidene glycinato diaqua cobalt (II) dimer] (SGCo) 2 , [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN) 2 , [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylidene glycinato diaqua zinc(II) dimer] (SGZ) 2 have been synthesized and characterized through a rapid, simple, and efficient methodology in excellent yield. These compounds were screened for In Vitro antibacterial activities against six pathogenic bacteria, such as Shigella sonnei , Escherichia coli , Bacilus subtilis , Sarcina lutea , Staphylococcus aureus and Pseudomonas arioginosa . The antibacterial activity was determined by the disc diffusion method using DMSO as solvent. The results indicate that (SGC) compound exhibit a significant antibacterial activity, depending on the bacterial strain and (SGCo) 2 , (SGN) 2 and (SGZ) 2 compounds show a moderate sensitivity even with higher doses. All these compounds were found to possess cytotoxic effect.