Here, the anti-inflammatory effect of Xylose-Taurine reduced (X-T-R), a taurine derivate was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. X-T-R reduced the generations of nitric oxide (NO) and prostaglandin E2 (PGE2) induced by the stimulation of LPS in RAW 264.7 by suppressing the protein expression of iNOS and COX-2 known as inflammatory mediators. Also, X-R-T reduced the expression levels of the pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF-α). Moreover, X-T-R inhibited the activation of nuclear factor-κB (NF-κB) and the phosphorylation of inhibitor κB (IκB)-α. In conclusion, these results first indicate that X-T-R inhibits LPS-induced inflammation by regulating the NF-κB signal pathway in macrophages.
CITATION STYLE
Lee, W. W., Kang, N., Park, S. Y., Cheong, S. H., Chang, K. J., Kim, S. H., … Ahn, G. (2017). Xylose-taurine reduced suppresses the inflammatory responses in lipopolysaccharide-stimulated Raw264.7 macrophages. Advances in Experimental Medicine and Biology, 975, 633–642. https://doi.org/10.1007/978-94-024-1079-2_49
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