Antiurolithiatic activity of pisonia alba leaves in experimental animal model (Albino Rats)

Abstract

Pisoniaalbais a medicinal plant used widely has a broad variety of pharmacological uses. The current research explored the acute toxicity of an ethanol sample of Pisoniaalba (Family: Nyctaginaceae) Ethanol Leaves Extract Pisoniaalba(ELPA) and Pisoniaalba(ALPA) Aqueous Leaves Extract at a dose of 1000mg / kg and comparison of urinary amount and electrolyte amount as parameters of evaluation. On the other side, urolithiasis caused by ethylene glycol (0.75% v / v in drinking water for 28 days) was used for the same ELPA and ALPA with an initial dose of 250 mg / kg in male rats for antiurolithiatic impact. As a conventional comparison drug, cystone (250 mg / kg, p.o.) was used amount of different urolithiatic parameters in the biological samples i.e (urine, serum and kidney homogenate) and renal function were used as criteria for evaluating the antiurolithiatic impact of ELPA and ALPA after 28days of therapy span results indicated that, in a model similar to that of furosemide, the ELPA and ALPA (250mg / kg) elevate blood quantity and urinary excretion of electrolytes. ELPA and ALPA reduced the excretion and deposition of multiple urolithiatic parameters in ethylene glycol-induced urolithiatic model relative to urolithiatic command in a pattern similar to cystone control. Supplementation with ELPA and ALPA also avoids renal function deficiency. According to our studies, ELPA supports stronger anti-urolithic exercise.