Genotipos de Streptococcus pneumoniae serotipo 3 en aislamientos invasivos en Colombia

Abstract

Introduction: Streptococcus pneumoniae serotype 3 is an important cause of pneumonia, bacteremia and meningitis. Objective: To establish the circulating genotypes of S. pneumoniae serotype 3 isolates recovered from invasive disease between 1994 to 2015 in Colombia. Materials and methods: Of the 365 S. pneumoniae serotype 3 isolates recovered through the laboratory national surveillance program, 117 isolates were analyzed. Pulsed-field gel electrophoresis was used for genotyping, and multilocus sequence typing was determined in representative isolates. Results: Frequency of this serotype increased from 2.7% between 1994 and 1998 to 9.1% between 2011 and 2015 (p = 0.000); 91.7% of the isolates showed a genetic similarity greater than 77% and were related to the Netherlands3-31(PMEN31) clone CC180. Several subtypes were identified, two of which showed antimicrobial resistance. Conclusion: In Colombia, the pneumococcal population of the capsular type 3 shows a continuous and homogeneous circulation, relating to the clonal group ST-180.