Lipid A has been found to be an inducer of IL-1 with similar potency as LPS. Partial structures of lipid A or core oligosaccharides are less active or not active at all. We propose that lipid A is the structure responsible for induction of immunostimulatory or immunoregulatory properties of LPS.
CITATION STYLE
Loppnow, H., Durrbaum, I., Brade, H., Dinarello, C. A., Kusumoto, S., Rietschel, E. T., & Flad, H. D. (1990). Lipid A, the immunostimulatory principle of lipopolysaccharides? In Advances in Experimental Medicine and Biology (Vol. 256, pp. 561–566). https://doi.org/10.1007/978-1-4757-5140-6_50
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