Experimental evidence for the role of atherosclerosis in calcific aortic valve disease

0Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Calcific aortic stenosis is the most common indication for surgical valve replacement in the United States (www.sts.com). Currently, in 2012 surgical valve replacement is the number one indication for the treatment of this disease process (Bonow et al. 1998). For years, this disease has been described as a passive phenomena during which serum calcium attaches to the valve surface and binds to the leaflet to form nodules. Over decades, as aortic stenosis progressed, it will cause progressive left ventricular hypertrophy, left ventricular diastolic and systolic dysfunction, congestive heart failure, angina, arrhythmias, and syncope. Recent studies demonstrate an association between atherosclerotic risk factors and aortic valve disease. Although a unifying hypothesis for the role of atherosclerotic risk factors towards the mechanism of vascular and aortic valve disease is emerging, progress in studying the cell biology of this disease has been defining turning point in understanding the overall mechanisms.

Cite

CITATION STYLE

APA

Subramaniam, M., Spelsberg, T. C., & Rajamannan, N. M. (2013). Experimental evidence for the role of atherosclerosis in calcific aortic valve disease. In Cardiac Valvular Medicine (pp. 23–33). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-4132-7_4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free