Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

Abstract

This chapter provides two protocols for the solid-phase synthesis of peptide thioesters using N α -Fmoc-protected amino acids. The first protocol is based on a so-called safety-catch linker, while the second relies on a backbone amide linker. © Springer Science+Business Media, New York 2013.