Granulocyte colony stimulating factor adjuvant role on the immunological response to Hepatitis B vaccine in patients with cirrhosis: A double blind randomized placebo controlled trial

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Abstract

Background: Patients with liver cirrhosis have usually poor antibody response to hepatitis B virus (HBV) vaccination. Objectives: This study aimed to investigate the effect of granulocyte colony stimulating factor (G-CSF) on increasing antibody titers, after HBV vaccination, in patients with liver cirrhosis waiting for transplantation. Patients and Methods: From 56 patients with cirrhosis, 28 patients were allocated to receive double dose HBV vaccine (40 μgr) plus G-CSF and 28 patients were allocated to receive double dose HBV vaccine (40 μgr) plus placebo. Injections were performed on weeks 0, 4 and 8 and the blood samples were obtained one month after each vaccination session. Results: There was no statistically significant difference between anti-HBV antibody titers in patients receiving double dose HBV vaccination plus G-CSF and patients receiving double dose HBV vaccination plus placebo, after first, second or third vaccination rounds (P > 0.05). Although the adjuvant G-CSF injection did not cause significant increased antibody titers in our patients compared to the placebo group, the increase in antibody titers following vaccination, happened faster in this group, compared to the placebo group. Conclusions: The present study showed that G-CSF is not superior to placebo in production of protective antibody titers after HBV vaccination but could result in a more rapid antibody response, compared to the placebo. © 2014, Kowsar Corp.

Figures

  • Figure 1. Flow Diagram of Trial
  • Table 1. Baseline Characteristics of the Patients a
  • Table 2. The Effect of G-CSF on anti HBV Antibody Titers After Each Round of HBV Vaccination
  • Table 3. Mean HBV Antibody Titers in Two Groups, Following First, Second and Third Sessions of Vaccinations a
  • Figure 2. Diagram Showing an Increase in Antibody Titers Following Vaccination

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CITATION STYLE

APA

Lankarani, K. B., Talebzadeh, M., Eshraghian, A., & Malek-Hosseini, S. A. (2014). Granulocyte colony stimulating factor adjuvant role on the immunological response to Hepatitis B vaccine in patients with cirrhosis: A double blind randomized placebo controlled trial. Hepatitis Monthly, 14(5). https://doi.org/10.5812/hepatmon.15447

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