Glioma-induced disruption of resting-state functional connectivity and amplitude of low-frequency fluctuations in the salience network

Abstract

BACKGROUND AND PURPOSE: Cognitive challenges are prevalent in survivors of glioma, but their neurobiology is incompletely understood. The purpose of this study was to investigate the effect of glioma presence and tumor characteristics on resting-state functional connectivity and amplitude of low-frequency fluctuations of the salience network, a key neural network associated with cognition. MATERIALS AND METHODS: Sixty-nine patients with glioma (mean age, 48.74 [SD, 14.32] years) who underwent resting-state fMRI were compared with 31 healthy controls (mean age, 49.68 [SD, 15.54] years). We identified 4 salience network ROIs: left/right dorsal anterior cingulate cortex and left/right anterior insula. Average salience network resting-state functional connectivity and amplitude of low-frequency fluctuations within the 4 salience network ROIs were computed. RESULTS: Patients with gliomas showed decreased overall salience network resting-state functional connectivity (P =.001) and increased amplitude of low-frequency fluctuations in all salience network ROIs (P,.01) except in the left dorsal anterior cingulate cortex. Compared with controls, patients with left-sided gliomas showed increased amplitude of low-frequency fluctuations in the right dorsal anterior cingulate cortex (P =.002) and right anterior insula (P,.001), and patients with right-sided gliomas showed increased amplitude of low-frequency fluctuations in the left anterior insula (P =.002). Anterior tumors were associated with decreased salience network resting-state functional connectivity (P