Prenylated 9,10-dihydrophenanthrenes from Macaranga javanica

Abstract

Phytochemical investigation of the acetone extract of Macaranga javanica leaves afforded three new prenylated 9,10-dihydrophenanthrenes, macajavanicins A-C (1-3). Structures of these compounds were elucidated mainly by NMR and mass spectral data. Along with compounds 1-3, two known prenylated dihydrostilenes, laevifolins A and B (4, 5), were also isolated. The presence of these new 9,10-dihydrophentanthrene derivatives is the first time in the genus Macaranga, and its chemotaxonomic significances are briefly discussed. The antibacterial properties of compounds 1-5 against eight pathogenic bacteria are also described.