Highly enantioselective Michael addition of aldehy des to nitroolefins catalyzed by primary amine thiourea organocatalysts

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Abstract

Asymmetric Michael addition reactions of aldehydes to nitroolefins have been successfully initiated by a series of primary amine thiourea bifunctional catalysts, with high enantioselectivities (90-98% ee) and excellent yields (80-96%).The privileged quinine scaffold was found to be essential to the reaction efficiency and enantioselectivity. © 2010 Elsevier Ltd.All rights reserved.

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Chen, J. R., Zou, Y. Q., Fu, L., Ren, F., Tan, F., & Xiao, W. J. (2010). Highly enantioselective Michael addition of aldehy des to nitroolefins catalyzed by primary amine thiourea organocatalysts. Tetrahedron, 66(29), 5367–5372. https://doi.org/10.1016/j.tet.2010.05.056

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