Effect of dropwort (Oenanthe javanica) Extracts on memory improvement in Alzheimer's disease animal model, Tg2576 mice

5Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

This study was conducted to investigate the effect of herbs on memory improvement by focusing on their cholinergic functions in Tg2576 mice. Seven herbs were used to obtain extracts by using alcohol and water. In screening test for cholinergic activities of the extracts, acetylcholinesterase (AChE) activity was highly inhibited in Oenanthe javanica alcohol extract (OJAE, 18.76%) as compared with the others. The OJAE-treated Tg2576 (Tg-OJAE) groups showed the statistically significant increases of latency time in passive avoidance test. Also, it was found that the concentration of Aβ1-42 was significantly reduced in Tg-OJAE groups compared to non-treated Tg2576 groups. In the additional enzyme test, it was found that IC50 of OJAE was 991.77 μg/mL and OJAE acted as an uncompetitive inhibitor of AChE. Therefore, it seemed that OJAE can be used for the development of processed foods for memory improvement.

Cite

CITATION STYLE

APA

Won, B. Y., Shin, K. Y., Ha, H. J., Chang, K. A., Yun, Y. S., Kim, Y. R., … Lee, H. G. (2015). Effect of dropwort (Oenanthe javanica) Extracts on memory improvement in Alzheimer’s disease animal model, Tg2576 mice. Korean Journal of Food Science and Technology, 47(6), 779–784. https://doi.org/10.9721/KJFST.2015.47.6.779

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free