Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2

48Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Factor Xa-induced stimulation of coronary artery smooth muscle cells (CASMC) was investigated by analyzing [3H]thymidine incorporation, cell proliferation, and ERK-1/2 activation. Exposure of the cells to factor Xa evoked a time-dependent activation of ERK-1/2 with increased [3H]thymidine incorporation and cell proliferation. The factor Xa-induced ERK-1/2 activation was not desensitized by preincubation of the cells with thrombin. However, ERK-1/2 activation was markedly attenuated by prior exposure of the cells to protease-activated receptor-2 (PAR-2) activating peptide, SLIGKV. The mitogenic effect of factor Xa was significantly reduced in the presence of anti-PAR-2 monoclonal antibody. Several lines of experimental evidence indicate that factor Xa-induced mitogenesis of CASMC is a cellular process mediated by PAR-2 activation. © 2002 Elsevier Science Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Koo, B. H., Chung, K. H., Hwang, K. C., & Kim, D. S. (2002). Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2. FEBS Letters, 523(1–3), 85–89. https://doi.org/10.1016/S0014-5793(02)02948-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free