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Methodology for identification of cysteine-reactive covalent inhibitors

Humana Press Inc., (2019), 245-262
DOI: 10.1007/978-1-4939-9187-7_15
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Abstract

Covalent fragments are an emerging technology to discover covalent ligands in target-based or phenotypic screens. Here we describe screening of cysteine-reactive covalent fragments against a protein of interest using mass spectrometry or enzymatic methods.

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Kathman, S. G., & Statsyuk, A. V. (2019). Methodology for identification of cysteine-reactive covalent inhibitors. In Methods in Molecular Biology (Vol. 1967, pp. 245–262). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9187-7_15

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