Decrease in tobacco consumption after treatment with topiramate and aripiprazole: A case report

Abstract

Introduction: A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the established addiction. Case presentation: We report the case of a 34-year-old man who compulsively smoked 80 to 100 cigarettes each day. After receiving treatment with topiramate and aripiprazole, his tobacco consumption was dramatically reduced. Conclusion: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/ or kainate blocking agents and a dopamine D2 receptor partial agonist may be novel instruments for nicotine abuse disorders. © 2008 Arbaizar et al; licensee BioMed Central Ltd.