Analysis of a post-translational oscillator using process algebra and spatio-temporal logic

Abstract

We describe the modelling of a post-translational oscillator using a process algebra and the specification of complex properties of its dynamics using a spatio-temporal logic. We show that specifications in the Logic of Behaviour in Context can be seen as hypotheses about oscillations and other biochemical behaviours, to be tested automatically by model-checking software. By using these techniques we show that the theoretical model behaves in a manner in keeping with known properties of biological circadian oscillators.