Glomerular filtration of albumin: How small is the sieving coefficient?

Abstract

A model was developed to describe how the concentration of albumin in proximal tubule fluid will vary with axial position, including the effects of luminal flow and water and albumin reabsorption. The results show that the high albumin sieving coefficients proposed recently cannot be reconciled with micropuncture data in rats. © 2004 by the International Society of Nephrology.