Thromboresistance and functional healing in the COBRA PzF stent versus competitor DES: Implications for dual antiplatelet therapy

30Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Aims: The aim of this study was to investigate the COBRA PzF stent (C-PzF) with respect to thrombogenicity and healing versus conventional drug-eluting stents (DES) in dedicated preclinical models to evaluate their suitability for short-term dual antiplatelet therapy (DAPT). Methods and results: To examine acute thrombogenicity, the C-PzF durable polymer drug-eluting stent (DP-DES), and a bioabsorable polymer DES (BP-DES) were compared in a porcine arteriovenous shunt model and in a rabbit model to evaluate endothelial coverage at 14 days. Barrier function at 28 days in the rabbit was assessed in the former stents as well as in a polymer-free DES (PF-BES). The number of clots by scanning electron microscopy (SEM) was significantly less in the C-PzF and DP-EES versus the BP-EES. Endothelial coverage at 14 days was significantly greater in the C-PzF versus the DP-EES and BP-EES by CD31/PECAM-1 positive area in confocal microscopy (CM) (24.7% vs 11.9% vs 3.7%, respectively) and SEM (99.0% vs 29.6% vs 17.7%, respectively). Barrier protein expression by CM for p120/vascularendothelial cadherin complex was significantly greater in the C-PzF versus the DP-EES, BP-EES, and PF-BES (82.6% vs 12.8% vs 14.4% vs 18.1%, respectively). The percentage of Evan's Blue positive area was least in the C-PzF versus all groups (22.0% vs 70.7% vs 66.4% vs 55.2%, respectively). Conclusions: The C-PzF demonstrated a unique combination of thrombogenicity and healing advantages compared to contemporary DES and may be uniquely suitable for very short-term DAPT.

References Powered by Scopus

Pathology of Drug-Eluting Stents in Humans. Delayed Healing and Late Thrombotic Risk

2624Citations
N/AReaders
Get full text

Signaling mechanisms regulating endothelial permeability

1463Citations
N/AReaders
Get full text

Blood-borne tissue factor: Another view of thrombosis

941Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Drug-eluting coronary stents: insights from preclinical and pathology studies

185Citations
N/AReaders
Get full text

Main-chain phosphorus-containing polymers for therapeutic applications

34Citations
N/AReaders
Get full text

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

29Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Jinnouchi, H., Mori, H., Cheng, Q., Kutyna, M., Torii, S., Sakamoto, A., … Finn, A. V. (2019). Thromboresistance and functional healing in the COBRA PzF stent versus competitor DES: Implications for dual antiplatelet therapy. EuroIntervention, 15(4), E342–E353. https://doi.org/10.4244/EIJ-D-18-00740

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

83%

Lecturer / Post doc 1

17%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

63%

Materials Science 1

13%

Chemistry 1

13%

Social Sciences 1

13%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free