The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β-keto esters and a β-ketosulfone was successful. In-line phase separation, by means of a continuous liquid–liquid separator, enabled direct telescoping with a thermal Wolff rearrangement.
CITATION STYLE
O’Mahony, R. M., Lynch, D., Hayes, H. L. D., Ní Thuama, E., Donnellan, P., Jones, R. C., … Maguire, A. R. (2017). Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process. European Journal of Organic Chemistry, 2017(44), 6533–6539. https://doi.org/10.1002/ejoc.201700871
Mendeley helps you to discover research relevant for your work.