Omega-3 fatty acid supplementation for depression in children and adolescents

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Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. Main Objective: This review aims to determine the impact of omega-3 PUFA supplementation versus a comparator (e.g. placebo, wait-list control) on clinician-diagnosed depression or self-reported depression symptoms in children and adolescents aged 6 to 19 years. Secondary objectives are: Estimate the size of the effect of omega-3 PUFAs on depression; Estimate the effect of each type of omega-3 PUFA (EPA or DHA), compared with placebo, on depression; Determine if the effect is modified by dosage, format (capsule or liquid), sex or age.




Campisi, S. C., Zasowski, C., Shah, S., Bradley-Ridout, G., Szatmari, P., & Korczak, D. (2021). Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database of Systematic Reviews, 2021(6).

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