Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats

29Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

This study examined whether the calcium antagonist nisoldipine can shift the relations between sodium excretion, papillary blood flow, renal interstitial pressure, and renal perfusion pressure toward lower pressures in spontaneously hypertensive rats. Mean arterial pressure decreased similarly by 9% and 12% in Wistar-Kyoto and spontaneously hypertensive rats after nisoldipine (0.5 μg/kg bolus+0.017 μg/kg/min). Urine flow and sodium excretion increased by 35% and 24% in Wistar-Kyoto rats after nisoldipine. In contrast, urine flow and sodium excretion rose by 121% and 132% in spontaneously hypertensive rats, and fractional sodium excretion rose from 1.9±0.3 to 4.2±0.4%. Control sodium excretion, papillary blood flow, and renal interstitial pressure were significantly lower in spontaneously hypertensive rats than in Wistar-Kyoto rats when compared at similar renal perfusion pressures. Sodium excretion, papillary blood flow, and renal interstitial pressure all increased in spontaneously hypertensive rats after nisoldipine, whereas it had no effect on papillary blood flow or renal interstitial pressure in Wistar-Kyoto rats. The relations among sodium excretion, papillary blood flow, renal interstitial pressure, and renal perfusion pressure were shifted toward lower pressures in spontaneously hypertensive rats given nisoldipine and became similar to those seen in Wistar-Kyoto rats. These results indicate that nisoldipine normalizes the relations among sodium excretion, renal interstitial pressure, papillary blood flow, and renal perfusion pressure in spontaneously hypertensive rats perhaps by correcting the defect in renal medullary perfusion associated with resetting of pressure natriuresis in this model of hypertension.

References Powered by Scopus

Pressure-diuresis in volume-expanded rats. Cortical and medullary hemodynamics

140Citations
N/AReaders
Get full text

Influence of kinins and angiotensin II on the regulation of papillary blood flow

119Citations
N/AReaders
Get full text

Multiple effects of calcium entry blockers on renal function in hypertension +a

114Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Renal autoregulation in health and disease

361Citations
N/AReaders
Get full text

The role of the kidney in hypertension

247Citations
N/AReaders
Get full text

The renal medulla and hypertension

215Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Fenoy, F. J., Kauker, M. L., Milicic, I., & Roman, R. J. (1992). Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats. Hypertension, 19(1), 49–55. https://doi.org/10.1161/01.HYP.19.1.49

Readers' Seniority

Tooltip

Professor / Associate Prof. 2

50%

PhD / Post grad / Masters / Doc 2

50%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

50%

Pharmacology, Toxicology and Pharmaceut... 1

25%

Sports and Recreations 1

25%

Save time finding and organizing research with Mendeley

Sign up for free