Synthesis of Fluorine-containing DL-Phenylalanine Derivatives

Abstract

This paper describes an extention of our previous work on the synthesis of fluorine containing alanine derivatives. Seven fluorine containing DL-phenylalanine derivatives have been prepared by the condensation reaction of fluorobenzyl chlorides, and trifluoromethyl-and chlorotrifluoromethylbenzyl chlorides with diethyl acetamidomalonate. It was found that the new trifluoromethyl -substituted phenylalanines have higher solubilities In water compared with those of the parent phenylalanine. © 1977, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.