Molecular target for treatment of non-alcoholic fatty liver disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) is on a rise and until now there has been no effective treatment. Recent researches have mainly focused on molecular mechanisms of NAFLD and metabolic disorders, involving studies on pregnane X receptor (PXR),forkhead box protein 01 (FOXO1), farnesoid X receptor (FXR),peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptor (THR), AMP-activated protein kinase (AMPK), p53, nuclear erythroid 2-related factor 2 (Nrf2), mitochondria, cannabinoid receptors, and bile-acid receptor. This review focused on these molecular mechanisms and discussed the potential values of the above targets for treatment of NAFLD.