Comparative evaluation of different bone markers in peri-implant crevicular fluid of immediate loaded and nonloaded dental implants

Abstract

Aim: The present study was conducted to determine different bone markers in immediate loaded and nonloaded dental implants. Materials and methods: It comprised of 60 patients (males-30, females-30) which were divided into two groups of 30 each. Group, I received immediate loaded dental implants, and group II received non-loaded dental implants. Modified bleeding on probing index, peri-implant sulcus depth was assessed in both groups at 1 month, 2 months, 3 months and 4 months. The crevicular fluid was obtained to determine bone markers levels such as transforming growth factor-alpha (TGF-α), osteocalcin (OCN), osteopontin (OPN), parathyroid hormone (PTH) and osteoprotegerin (OPG). Results: Both groups revealed non- significant difference in modified bleeding on probing index and peri-implant sulcus depth (p > 0.05). Bone markers found to be elevated more in group I as compared to group II. However, the difference was non- significant (p > 0.05). Conclusion: Transforming growth factor alpha (TGF-α), OCN, OPN, OPG and PTH and parathyroid hormone (PTH) levels were higher in immediate loaded dental implants as compared to nonloaded dental implants. Clinical significance: Immediate loaded dental implants showed an increase in expression of bone markers such as TNF-α, OCN, OPN, PTH and OPG which may be useful in deciding future of immediate loaded dental implants.