Communicating assemblies of biomimetic nanocapsules

Abstract

Communication assemblies between biomimetic nanocapsules in a 3D closed system with self-regulating and self-organization functionalities were demonstrated for the first time. Two types of biomimetic nanocapsules, TiO2/polydopamine capsules and SiO2/polyelectrolytes capsules with different stimuli-responsive properties were prepared and leveraged to sense the external stimulus, transmit chemical signaling, and autonomic communication-controlled release of active cargos. The capsules have clear core-shell structures with average diameters of 30 nm and 25 nm, respectively. The nitrogen adsorption-desorption isotherms and thermogravimetric analysis displayed their massive pore structures and encapsulation capacity of 32% of glycine pH buffer and 68% of benzotriazole, respectively. Different from the direct release mode of the single capsule, the communication assemblies show an autonomic three-stage release process with a "jet lag"feature, showing the internal modulation ability of self-controlled release efficiency. The control overweight ratios of capsules influences on communication-release interaction between capsules. The highest communication-release efficiency (89.6% of benzotriazole) was achieved when the weight ratio of TiO2/polydopamine/SiO2/polyelectrolytes capsules was 5 : 1 or 10 : 1. Communication assemblies containing various types of nanocapsules can autonomically perform complex tasks in a biomimetic fashion, such as cascaded amplification and multidirectional communication platforms in bioreactors.