Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer

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Abstract

Polyphenols are abundant in vegetables and fruit. They have been shown to have various antitumor, antioxidant, and anti- inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato (Ipomoea batatas). These lipid-soluble polyphenols mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemo- sensitizing effects of lipid-soluble polyphenols on E0771 murine breast cancer cells. The lipid-soluble polyphenols accumulated in the cells’ cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The lipid-soluble polyphenols also arrested the cell cycle at G0/G1 by suppressing Akt activity, and enhanced the cytotoxicity of anti- cancer agents. In this model, lipid-soluble polyphenols inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of lipid-soluble polyphenols as a functional food to support cancer therapy.

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Kato, K., Nagane, M., Aihara, N., Kamiie, J., Miyanabe, M., Hiraki, S., … Yamashita, T. (2021). Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer. Journal of Clinical Biochemistry and Nutrition, 68(3), 193–200. https://doi.org/10.3164/JCBN.20-73

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