The effect of caffeine ingestion on pharmacokinetics of caffeine and its metabolites after a single administration in pregnant rats*

Abstract

The pharmacokinetics of caffeine and its metabolites were studied in pregnant rats in order to clarify the effects of maternal caffeine ingestion on the caffeine disposition. On gestational day 18 the single intravenous or oral 10 mg/kg dose of caffeine was administered to pregnant rats who had received drinking water containing 0.04% caffeine or water ad lib during the premating and/or pregnant periods. Concentrations of caffeine and its dimethyl-xanthines were simultaneously determined by high-performance liquid chromatography. © 1985, The Pharmaceutical Society of Japan. All rights reserved.