Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression*

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Abstract

The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayedtype hypersensitivity (DTH) and for helper functions were found to be Ly1+,2− in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly1−,2+. Unlike some primed helper cells, T cells involved in DTH were Ia−. Suppressor cells in the system studied were Ia+. © 1976, Rockefeller University Press., All rights reserved.

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Vadas, M. A., Miller, J. F. A. P., McKenzie, I. F. C., Chism, S. E., Shen, F. W., Boyse, E. A., … Whitelaw, A. M. (1976). Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression*. Journal of Experimental Medicine, 144(1), 10–19. https://doi.org/10.1084/jem.144.1.10

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