Ambient Ultraviolet Radiation and Sebaceous Carcinoma Incidence in the United States, 2000-2016

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Abstract

Sebaceous carcinoma (SC) is an aggressive skin tumor. Although ultraviolet radiation (UVR) is an important risk factor for some skin cancer types, no population-level study has evaluated for an association between UVR and SC risk. Herein, we examined satellite-based ambient UVR in relation to SC incidence using Surveillance, Epidemiology, and End Results 18 cancer registry data (2000-2016). There were 3503 microscopically confirmed cases of SC diagnosed during the study period. For non-Hispanic whites, there was an association between increasing ambient UVR and SC risk (incidence rate ratio [per UVR quartile] 1.15, 95% confidence interval 1.11 to 1.19; two-sided P001) including among individuals with and without putative Muir-Torre syndrome. In contrast, there was no association between ambient UVR and SC risk for other race and ethnicities. Our findings support a role for UVR in SC tumorigenesis, which suggests that photoprotection may reduce SC risk, particularly for high-risk populations (eg, Muir-Torre syndrome).

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Sargen, M. R., Mai, Z. M., Engels, E. A., Goldstein, A. M., Tucker, M. A., Pfeiffer, R. M., & Cahoon, E. K. (2020). Ambient Ultraviolet Radiation and Sebaceous Carcinoma Incidence in the United States, 2000-2016. JNCI Cancer Spectrum, 4(2). https://doi.org/10.1093/JNCICS/PKAA020

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