Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
CITATION STYLE
Simms, J., Hall, N. E., Lam, P. H. C., Miller, L. J., Christopoulos, A., Abagyan, R., & Sexton, P. M. (2009). Homology modeling of GPCRs. Methods in Molecular Biology (Clifton, N.J.), 552, 97–113. https://doi.org/10.1007/978-1-60327-317-6_7
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