ELEKTROSPİNNİNG PARAMETRELERİNİN JELATİN/BİYOAKTİF CAM NANOLİF YAPISI ÜZERİNDEKİ ETKİLERİNİN İNCELENMESİ

Abstract

In the present study, an electrospinning procedure was carried out in order to develop a simple and effective tool for fabricating gelatin/bioactive glass (Gt/BG) nanofibers with a controllable and predictable fiber diameter. For this purpose, a quadratic model was obtained within the context of response surface methodology based on a three-level, three-variable Box–Behnken design technique to describe the relationship between the fiber diameter and the electrospinning parameters, namely BG content, tip-to-collector distance, and flow rate. Meanwhile, the quality of fit of the model was evaluated by the coefficients of determination (R-square) and the analysis of variances. Moreover, the adequacy of the model was examined by conducting additional experiments that were not employed in the model generation