Functionalized 2,2’-bipyrroles: Building blocks for Pyrrolic macrocycles

Abstract

Functionalized N-unsubstituted 2,2’-bipyrroles are basic building blocks for the preparation of pyrrolic macrocycles and natural products, such as prodigiosines. The aim of this review is to provide a description of the most important methodologies used to prepare 2,2’-bipyrroles and their central role as building blocks for the synthesis of porphyrinoids and property-defining structural elements therein.