Il1rap pulls a double shift in the cysteine factory

Abstract

Anoikis is a critical barrier to cancer cell metastasis. In this issue of Cancer Discovery, Zhang and col-leagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the − activity of the system Xc cystine/glutamate antiporter and cystathionine γ-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification.