Resonant Waveguide Grating Biosensor for Microarrays

Abstract

A microarray consists of an indexed series of micron-sized spots of biological specimens for biomolecular interaction analysis. Microarray technologies present miniaturized and multiplexed approaches for sensitive and selective profiling of genes, proteins, and/or small molecules. Concurrent with the increasing applications of microarrays is the continuous efforts in developing novel detection systems for improving sensitivity and reliability in signal detection. This chapter describes the concept and applications of microarray technologies, and the principle of detection with an emphasis of resonant waveguide grating biosensor for microarray-based assays.