Enantioselective Acyl-Transfer/Protonation Reactions with Designed Chiral Thiourea-Iminophosphorane Catalysts

Abstract

A designed chiral thiourea-iminophosphorane catalyst was developed to afford α-acyloxythioesters through enantioselective acyl-transfer/protonation of α-acyloxy-β-ketosulfides. The desired reaction proceeded in good yields with high enantioselectivities using a chiral thiourea-iminophosphorane bearing a pyrrolidine scaffold.