Association of diabetes and tuberculosis: Impact on treatment and post-treatment outcomes

230Citations
Citations of this article
448Readers
Mendeley users who have this article in their library.

Abstract

Objective: To determine the clinical consequences of pulmonary tuberculosis (TB) among patients with diabetes mellitus (DM). Methods: We conducted a prospective study of patients with TB in Southern Mexico. From 1995 to 2010, patients with acid-fast bacilli or Mycobacterium tuberculosis in sputum samples underwent epidemiological, clinical and microbiological evaluation. Annual follow-ups were performed to ascertain treatment outcome, recurrence, relapse and reinfection. Results: The prevalence of DM among 1262 patients with pulmonary TB was 29.63% (n=374). Patients with DM and pulmonary TB had more severe clinical manifestations (cavities of any size on the chest x-ray, adjusted OR (aOR) 1.80, 95% CI 1.35 to 2.41), delayed sputum conversion (aOR 1.51, 95% CI 1.09 to 2.10), a higher probability of treatment failure (aOR 2.93, 95% CI 1.18 to 7.23), recurrence (adjusted HR (aHR) 1.76, 95% CI 1.11 to 2.79) and relapse (aHR 1.83, 95% CI 1.04 to 3.23). Most of the second episodes among patients with DM were caused by bacteria with the same genotype but, in 5/26 instances (19.23%), reinfection with a different strain occurred. Conclusions: Given the growing epidemic of DM worldwide, it is necessary to add DM prevention and control strategies to TB control programmes and vice versa and to evaluate their effectiveness. The concurrence of both diseases potentially carries a risk of global spreading, with serious implications for TB control and the achievement of the United Nations Millennium Development Goals.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Jiménez-Corona, M. E., Cruz-Hervert, L. P., García-García, L., Ferreyra-Reyes, L., Delgado-Sánchez, G., Bobadilla-Del-Valle, M., … Ponce-De-León, A. (2013). Association of diabetes and tuberculosis: Impact on treatment and post-treatment outcomes. Thorax, 68(3), 214–220. https://doi.org/10.1136/thoraxjnl-2012-201756

Readers over time

‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24020406080

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 161

62%

Researcher 59

23%

Lecturer / Post doc 22

9%

Professor / Associate Prof. 16

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 179

69%

Nursing and Health Professions 35

14%

Agricultural and Biological Sciences 24

9%

Biochemistry, Genetics and Molecular Bi... 20

8%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0