Mania in a Patient with Wilson's Disease Awaiting Liver Transplant

Abstract

Miss AC, a 19-year-old woman, had been diagnosed with Wilson's disease 2 years before the onset of her neuropsychiatric manifestations. She had developed ascites and other features suggestive of chronic liver disease. Her liver function tests, serum ceruloplasmin levels, urine copper levels, and serum copper levels were suggestive of Wilson's disease. The patient was transferred to psychiatry for management of these behavioral problems. Her mental status examination revealed over-familiarity, distractibility, euphoric affect, increased psychomotor activity, and delusions of grandiosity with poor insight and judgment. There is a paucity of literature available regarding the treatment options in psychiatrically ill patients with Wilson's disease. Multi-system involvement in Wilson's disease can make the traditional medications difficult to use in these patients, and treatment regimens may need to be individualized. (PsycINFO Database Record (c) 2012 APA, all rights reserved)