Urotensin II evokes potent vasoconstriction in humans in vivo

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Abstract

The peptide urotensin II (U II) evokes potent vasoconstriction in non-human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation or no response. It is therefore of importance to determine the vascular effect of U II in humans in vivo. U II (0.1-300 pmol min-1) was infused into the brachial artery of nine healthy volunteers. Changes in forearm blood flow (FBF) were determined by venous occlusion plethysmography. U II induced dose-dependent reduction in FBF. A threshold response was obtained by 1 pmol min-1, and the highest dose of U II (300 pmol min-1) reduced FBF by 31±4% (P<0.01). FBF returned to baseline values within 30 min. This study demonstrates that U II produces potent vasoconstriction in humans in vivo.

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Böhm, F., & Pernow, J. (2002). Urotensin II evokes potent vasoconstriction in humans in vivo. British Journal of Pharmacology, 135(1), 25–27. https://doi.org/10.1038/sj.bjp.0704448

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