Cocaine modulates locomotion behavior in C. elegans

43Citations
Citations of this article
61Readers
Mendeley users who have this article in their library.

Abstract

Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter). Cocaine administration induces complex behavioral alterations in mammals, but the underlying mechanisms are not well understood. Here, we tested the effect of cocaine on C. elegans behavior. We show for the first time that acute cocaine treatment evokes changes in C. elegans locomotor activity. Interestingly, the neurotransmitter serotonin, rather than dopamine, is required for cocaine response in C. elegans. The C. elegans SERT MOD-5 is essential for the effect of cocaine, consistent with the role of cocaine in targeting monoamine transporters. We further show that the behavioral response to cocaine is primarily mediated by the ionotropic serotonin receptor MOD-1. Thus, cocaine modulates locomotion behavior in C. elegans primarily by impinging on its serotoninergic system. © 2009 Ward et al.

Cite

CITATION STYLE

APA

Ward, A., Walker, V. J., Feng, Z., & Xu, X. Z. S. (2009). Cocaine modulates locomotion behavior in C. elegans. PLoS ONE, 4(6). https://doi.org/10.1371/journal.pone.0005946

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free