Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia

  • P Nicot C
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Abstract

While telomerase (hTERT) activity is absent from normal somatic cells, reactivation of hTERT expression is a hallmark of cancer cells. Telomerase activity is required for avoiding replicative senescence and supports immortalization of cellular proliferation. Only a minority of cancer cells rely on a telomerase-independent process known as alternative lengthening of telomeres, ALT, to sustain cancer cell proliferation. Multiple genetic, epigenetic, and viral mechanisms have been found to de-regulate telomerase gene expression, thereby increasing the risk of cellular transformation. Here, we review the different strategies used by the Human T-cell leukemia virus type 1, HTLV-I, to activate hTERT expression and stimulate its enzymatic activity in virally infected CD4 T cells. The implications of hTERT reactivation in HTLV-I pathogenesis and disease treatment are discussed.

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P Nicot, C. (2015). Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia. International Journal of Cancer and Oncology, 2(2), 1–8. https://doi.org/10.15436/2377-0902.15.017

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