BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

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Abstract

We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs). BACH1-deficient cells were also sensitive to mitomycin C (MMC) and underwent MMC-induced chromosome instability. Moreover, we identified a homozygous nonsense mutation in BACH1 in a FA-J patient-derived cell line and could not detect BACH1 protein in this cell line. Expression of wild-type BACH1 in this cell line reduced the accumulation of cells at G2/M phases following exposure to DNA crosslinkers, a characteristic of Fanconi anemia (FA) cells. These results support the conclusion that BACH1 is FANCJ. Copyright © 2005 Elsevier Inc.

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Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., … Cantor, S. B. (2005). BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell, 8(3), 255–265. https://doi.org/10.1016/j.ccr.2005.08.004

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