Autologous matrix-induced chondrogenesis (AMIC)-aided repair of osteochondral lesions of the talus

Abstract

The autologous matrix-induced chondrogenesis (AMIC) technique was first reported by Behrens in 2005 [1, 2] and has been initially described for treatment of full-thickness cartilage defects in the knee joint [3, 4]. This one-step procedure combines debridement of the cartilage lesion and microfracturing of the subchondral bone to release bone marrow, containing mesenchymal stem cells (MSCs). The defect is then covered by a commercially available collagen I/III matrix to cover and stabilise the resulting blood clot. The scaffold is fixed with autologous or partial autologous fibrin glue [5].