The first derivatives of gelatin and type I collagen fluorescence spectra were characterized in order to describe the effect of free radicals on pyridinoline (PYD) cross-links. The different gas saturation conditions were used to investigate the effect of different free radicals. An analysis of first derivative fluorescence spectra suggests that PYD cross-link fluorescence emission is composed of three peaks in gelatin, but only two in type I collagen. The PYD cross-link was photo-degraded more than other gases in the presence of O2. This suggests that the singlet oxygen (1O2) plays a key role when using photodynamic therapy to treat skin fibrosis disease with Hypocrellin B (HB).
CITATION STYLE
Yan, H., Chen, Y., Zhang, J., Liu, W., & Chen, R. (2016). The role of free radicals in the photodynamic treatment of fibrotic skin diseases. In Advances in Experimental Medicine and Biology (Vol. 923, pp. 69–74). Springer New York LLC. https://doi.org/10.1007/978-3-319-38810-6_10
Mendeley helps you to discover research relevant for your work.