Hypoxia and the receptor for advanced glycation end products (RAGE) signaling in cancer

Abstract

Hypoxia is characterized by an inadequate supply of oxygen to tissues, and hypoxic re-gions are commonly found in solid tumors. The cellular response to hypoxic conditions is mediated through the activation of hypoxia-inducible factors (HIFs) that control the expression of a large number of target genes. Recent studies have shown that the receptor for advanced glycation end products (RAGE) participates in hypoxia-dependent cellular adaptation. We review recent evidence on the role of RAGE signaling in tumor biology under hypoxic conditions.