Adding insult to injury: Cochlear nerve degeneration after "temporary" noise-induced hearing loss

1.9kCitations
Citations of this article
1.2kReaders
Mendeley users who have this article in their library.

Abstract

Overexposure to intense sound can cause temporary or permanent hearing loss. Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of damage to delicate mechano-sensory and neural structures of the inner ear and no persistent or delayed consequences for auditory function. Here, we show, using cochlear functional assays and confocal imaging of the inner ear in mouse, that acoustic overexposures causing moderate, but completely reversible, threshold elevation leave cochlear sensory cells intact, but cause acute loss of afferent nerve terminals and delayed degeneration of the cochlear nerve. Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more widespread than are revealed by conventional threshold testing. This primary neurodegeneration should add to difficulties hearing in noisy environments, and could contribute to tinnitus, hyperacusis, and other perceptual anomalies commonly associated with inner ear damage. Copyright © 2009 Society for Neuroscience.

References Powered by Scopus

Mechanics of the mammalian cochlea

1195Citations
N/AReaders
Get full text

Evoked otoacoustic emissions arise by two fundamentally different mechanisms: A taxonomy for mammalian OAEs

608Citations
N/AReaders
Get full text

Far-field acoustic response: Origins in the cat

555Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model

755Citations
N/AReaders
Get full text

Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines

682Citations
N/AReaders
Get full text

Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates

588Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Kujawa, S. G., & Liberman, M. C. (2009). Adding insult to injury: Cochlear nerve degeneration after “temporary” noise-induced hearing loss. Journal of Neuroscience, 29(45), 14077–14085. https://doi.org/10.1523/JNEUROSCI.2845-09.2009

Readers over time

‘09‘10‘11‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘2404590135180

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 484

62%

Researcher 205

26%

Professor / Associate Prof. 82

10%

Lecturer / Post doc 15

2%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 193

31%

Medicine and Dentistry 191

31%

Neuroscience 160

26%

Engineering 82

13%

Article Metrics

Tooltip
Mentions
Blog Mentions: 2
News Mentions: 35
References: 2
Social Media
Shares, Likes & Comments: 38

Save time finding and organizing research with Mendeley

Sign up for free
0