Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: Evidence from a meta-analysis

Abstract

Background: Previous studies investigating the association between TP53 Arg72Pro polymorphism and gastric cancer (GC) risk in Asian population have reported controversial results. Thus, a meta-analysis was performed. Methods: A comprehensive literature search was conducted and 17 case-control studies were finally included, involving a total of 5,990 GC cases and 6,812 controls. Subgroup analyses were performed by the sample size. Results: Meta-analysis of all 17 studies showed variant genotypes of TP53 Arg72Pro to be associated with an elevated GC risk in three genetic comparison models (ORPro vs. Arg =1.13, 95%CI 1.03-1.25, POR=0.01; ORHomozygote comparison model =1.33, 95%CI 1.07-1.64, POR=0.009; ORDominant genetic model =1.13, 95%CI 1.05-1.22, POR=0.002). Besides, a more obvious association was observed after the heterogeneity was decreased (all P values less than 0.001). This association was further identified by both subgroup and sensitivity analyses. Conclusions: This meta-analysis suggests the Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians.