Immunomodulatory activity of phenolic fraction from piper borbonense and cassytha filiformis growing in comoros islands

Abstract

Cassytha filiformis L. and Piper borbonense C. DC. are used as ethnical medicine for diversediseases in Comoros islands. This study aims to evaluate the potential immunomodulator properties ex-vivo of the phenolic fraction provided of the methanol extract of these plants by flow cytometer. Theresults highlighted an immunosuppressive effect on lymphocyte subpopulations for all doses administered intraperitoneally (i.p.) compared to the control group. The most immunosuppressive activity was observed at doses of 25 and 100 mg/kg b.w. respectively for Cassytha filiformis and Piper borbonense. However, an interesting immunostimulant activity was noted on monocytes for all doses and on granulocytes for doses of 50 and 100 mg/kg b.w. in treated group with Cassytha filiformis. The same result wasobserved for P. borbonense on granulocytes for all doses. This immunostimulant effect observed on granulocytes can suggest a possible anti-inflammatory potency of these plants and an eventual use of these plants in the treatment of inflammatory symptoms diseases