Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings

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Abstract

The aim of this study was to summarize the current knowledge of paraneoplastic syndromes involving eyes. The main interest was the immunopathogenesis of the abovementioned entities. A web search was conducted using Medline, Web of Science and Scopus engines. Key words concerning ocular paraneoplastic syndromes (OPS) such as: "ocular paraneoplastic syndrome", "cancer-associated retinopathy", "cancer-associated cone dysfunction", "melanoma-associated retinopathy", "bilateral diffuse uveal melanocytic proliferation", and "paraneoplastic optic neuritis" were combined with "immunology", "immune response", "antibodies", or "autoantibodies". Numerous papers were found as a result of "ocular paraneoplastic syndrome" search and many of them matched the chosen criteria. We focused on the most recent papers - published in the last 5 years - And eventually, 92 items were found. Only several papers from each detailed category fulfilled both OPS and immunologic criteria. Site-specific paraneoplastic syndromes still remain a difficult clinical challenge. The immunopathogenesis of some of them seems to be more complex than previously thought.

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Kordys, M., Przezdziecka-Dołyk, J., Turno-Krecicka, A., & Misiuk-Hojło, M. (2018, October 1). Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings. Advances in Clinical and Experimental Medicine. Wroclaw University of Medicine. https://doi.org/10.17219/acem/73860

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