Persistence of dengue genome in a remotely infected patient

1Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

Abstract

Background: Dengue virus infection is an intriguing illness. It is traditionally thought of as a self-limited and nonpersistent disease. Objectives: We report a case with persistent dengue virus genome detectable in hematopoietic cells of a person with remote infection. Methods: A patient with multiple myeloma in remission was prepared for peripheral blood stem cell (PBSC) transplantation. Plasma and G-CSF-stimulated, mobilized PBSCs were collected. Dengue-specific reverse transcription polymerase chain reaction (RT-PCR) was performed in both pre- and post-stimulated blood specimens. Anti-dengue antibodies by ELISA and by neutralization assay were measured before and after the stem cell mobilization. Results: The viral genome was detected only in the PBSC of the post-G-CSF-stimulated specimens. Anti-dengue antibodies were negative and positive, by ELISA and neutralization assays, respectively, both before and after stem cell mobilization. Conclusion: Our findings reveal a persistent infection. Whether and how this strain may interact with subsequent serotype(s) remains to be elucidated.

Cite

CITATION STYLE

APA

Thaivanich, S., Visuthranukul, J., Arunyingmongkol, K., Bunworasate, U., Siriyasatien, P., & Kulwichit, W. (2023). Persistence of dengue genome in a remotely infected patient. Asian Biomedicine, 17(6), 287–290. https://doi.org/10.2478/abm-2023-0072

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free