The sensitivity to cytotoxic agents of the EMT6 tumour in vivo. comparative response of lung nodules in rapid exponential growth and of the solid flank tumour

Abstract

Experiments are described in which dose-response data have been obtained for EMT6 mouse tumour cells growing in vivo and exposed to various cytotoxic agents. A comparison has been made of the response of solid tumours in the flank and of rapidly growing lung nodules. The results are discussed with regard to their cell kinetic implications and compared with our results for the chemosensitivity of EMT6 cells in exponential and plateau phase growth in vitro. © 1976, Cancer Research Campaign. All rights reserved.